靶标:
PPAT
产品别名:
ATASE; GPAT; PRAT; PPAT; phosphoribosyl pyrophosphate amidotransferase; phosphoribosyl pyrophosphate amidotransferase; amidophosphoribosyltransferase; glutamine PRPP amidotransferase; glutamine phosphoribosylpyrophosphatate amidotransferase; glutamine phosphoribosylpyrophosphate amidotransferase; 谷氨酰胺磷酸核糖基焦磷酸酰胺基转移酶;
背景信息:
The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region.