靶标：
PLOD1
产品别名：
EDS6； EDSKCL1； LH； LH1； LLH； PLOD； PLOD1； procollagen-lysine,2-oxoglutarate 5-dioxygenase 1； procollagen-lysine,2-oxoglutarate 5-dioxygenase 1； procollagen-lysine,2-oxoglutarate 5-dioxygenase 1； lysine hydroxylase； lysyl hydroxlase 1； procollagen lysyl hydroxylase 1； procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1； 前胶原赖氨酸-1,2-酮戊二酸-5-双加氧酶1(PLOD1)；
背景信息：
Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015],
