靶标：
PLAT
产品别名：
T-PA； TPA； PLAT； plasminogen activator, tissue type； plasminogen activator, tissue type； tissue-type plasminogen activator； alteplase； plasminogen/activator kringle； reteplase； t-plasminogen activator； 组织型纤溶酶原激活剂； 组织型纤溶酶原激活因子(tPA)； 组织型纤溶酶原激活蛋白；
背景信息：
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016],
