靶标：
PER1
产品别名：
PER； RIGUI； hPER； PER1； period circadian regulator 1； period circadian regulator 1； period circadian protein homolog 1； Period, drosophila, homolog of； circadian clock protein PERIOD 1； circadian pacemaker protein RIGUI； hPER1； period circadian clock 1； period homolog 1； 昼夜节律蛋白1(PER1)； 节律抑制蛋白PER1；
背景信息：
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described. [provided by RefSeq, Jan 2014],
