靶标：
ENPP2
产品别名：
ATX； ATX-X； AUTOTAXIN； LysoPLD； NPP2； PD-IALPHA； PDNP2； ENPP2； ectonucleotide pyrophosphatase/phosphodiesterase 2； ectonucleotide pyrophosphatase/phosphodiesterase 2； ectonucleotide pyrophosphatase/phosphodiesterase family member 2； E-NPP 2； autotaxin-t； extracellular lysophospholipase D； phosphodiesterase I/nucleotide pyrophosphatase 2； plasma lysophospholipase D； 外核苷酸焦磷酸酶/磷酸二酯酶2(ENPP2)； 核苷酸焦磷酸酶2； 自分泌运动因子；
背景信息：
The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008],
