靶标:
NPTX2
产品别名:
NARP; NP-II; NP2; NPTX2; neuronal pentraxin 2; neuronal pentraxin 2; neuronal pentraxin-2; apexin; neuronal activity-regulated pentaxin; neuronal pentraxin II; 神经元正五聚蛋白Ⅱ(NPTX2); 神经细胞穿透素2;
背景信息:
This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. [provided by RefSeq, Feb 2009],