靶标:
MEST
产品别名:
PEG1; MEST; mesoderm specific transcript; mesoderm specific transcript; mesoderm-specific transcript homolog protein; paternally-expressed gene 1 protein; 中胚层特异性转录同源蛋白MEST;
背景信息:
This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15.