靶标：
MCC
产品别名：
MCC1； MCC； MCC regulator of WNT signaling pathway； MCC regulator of WNT signaling pathway； colorectal mutant cancer protein； MCC, WNT signaling pathway regulator； mutated in colorectal cancers； 大肠癌肿瘤突变蛋白；
背景信息：
MUTATED IN COLORECTAL CANCERS(MCC) is a tumor suppressor gene. It is mapped to 5q22.2. This gene suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. MCC also Inhibits DNA binding of b-catenin/TCF/LEF transcription factors, and it is Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase(PAK) activation. What's more, MCC can interact with SCRIB(via phosphorylated PDZ-binding motif), EZR, SNX27, SLC9A3R1 and SLC9A3R2.
