靶标：
KCNJ1
产品别名：
KIR1.1； ROMK； ROMK1； KCNJ1； potassium inwardly rectifying channel subfamily J member 1； potassium inwardly rectifying channel subfamily J member 1； ATP-sensitive inward rectifier potassium channel 1； ATP-regulated potassium channel ROM-K； inward rectifier K(+) channel Kir1.1； inwardly rectifying K+ channel； potassium channel, inwardly rectifying subfamily J member 1； potassium voltage-gated channel subfamily J member 1； ATP调节钾离子通道ROM K； 细胞内流钾通道蛋白KCNJ1；
背景信息：
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
