靶标：
KCNA1
产品别名：
AEMK； EA1； HBK1； HUK1； KV1.1； MBK1； MK1； RBK1； KCNA1； potassium voltage-gated channel subfamily A member 1； potassium voltage-gated channel subfamily A member 1； potassium voltage-gated channel subfamily A member 1； potassium channel, voltage gated shaker related subfamily A, member 1； potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)； voltage-gated K(+) channel HuKI； voltage-gated potassium channel HBK1； voltage-gated potassium channel subunit Kv1.1； 钾通道蛋白1；
背景信息：
This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). [provided by RefSeq, Jul 2008],
