靶标：
IL12RB2
产品别名：
IL12RB2； interleukin 12 receptor subunit beta 2； interleukin 12 receptor subunit beta 2； interleukin-12 receptor subunit beta-2； IL-12 receptor subunit beta-2； IL-12R subunit beta-2； interleukin 12 receptor, beta 2； interleukin-12 receptor beta-2 chain； 白介素12受体β2(IL12Rb2)； 白细胞介素-12受体β2；
背景信息：
interleukin 12 receptor subunit beta 2(IL12RB2) Homo sapiens The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012],
