靶标:
ICA1
产品别名:
ICA69; ICAp69; ICA1; islet cell autoantigen 1; islet cell autoantigen 1; islet cell autoantigen 1; 69 kDa islet cell autoantigen; diabetes mellitus type I autoantigen; islet cell autoantigen 1, 69kDa; islet cell autoantigen p69; p69; testicular tissue protein Li 162; 胰岛细胞自身抗原1; 胰岛细胞自身抗原1(ICA1);
背景信息:
Islet cell autoantigen 1 is a protein that in humans is encoded by the ICA1 gene. It is mapped to 7p22. This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. What’s more, this protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants encoding two different isoforms have been found for this gene.