靶标:
HTR2A
产品别名:
5-HT2A; HTR2; HTR2A; 5-hydroxytryptamine receptor 2A; 5-hydroxytryptamine receptor 2A; 5-hydroxytryptamine receptor 2A; 5-HT2 receptor; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; serotonin 5-HT-2A receptor; 5-羟色胺受体2A; 5-羟色胺受体2A(HTR2A);
背景信息:
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009],