靶标:
HSPA9
产品别名:
CRP40; CSA; EVPLS; GRP-75; GRP75; HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN; SIDBA4; HSPA9; heat shock protein family A (Hsp70) member 9; heat shock protein family A (Hsp70) member 9; stress-70 protein, mitochondrial; 75 kDa glucose-regulated protein; catecholamine-regulated protein 40; epididymis secretory sperm binding protein Li 124m; heat shock 70kD protein 9B; heat shock 70kDa protein 9 (mortalin); mortalin, perinuclear; mortalin-2; mortalin2; p66-mortalin; peptide-binding protein 74; 70kDa热休克蛋白9(HSPA9); G蛋白偶联受体75;
背景信息:
Grp75,也称作死亡蛋白,是无热诱导性的伴侣蛋白 Hsp70 家族成员 (1,2)。该蛋白是多种线粒体蛋白从细胞浆转运至线粒体所必需的蛋白 (3)。Grp75 使抑癌基因 p53 失活 (4)。研究发现,Grp75 在许多肿瘤组织和永生化人细胞系中过表达,这表明其在肿瘤形成中发挥作用 (5)。Grp75 还与细胞衰老有关,因 Grp75 过表达似乎能延长人成纤维细胞的寿命 (6)。