靶标:
DNAJA1
产品别名:
DJ-2; DjA1; HDJ2; HSDJ; HSJ-2; HSJ2; HSPF4; NEDD7; hDJ-2; DNAJA1; DnaJ heat shock protein family (Hsp40) member A1; DnaJ heat shock protein family (Hsp40) member A1; dnaJ homolog subfamily A member 1; DnaJ (Hsp40) homolog, subfamily A, member 1; dnaJ protein homolog 2; heat shock 40 kDa protein 4; heat shock protein J2; heat shock protein, DNAJ-like 2; human DnaJ protein 2; neural precursor cell expressed, developmentally down-regulated 7; 40kDa热休克蛋白4(HSPF4); 热休克蛋白相关蛋白4;
背景信息:
HSPA8/Hsc70的共同伴侣。刺激ATP水解,但不刺激HSPA1A介导的展开蛋白的折叠。在蛋白质转运到线粒体中起作用,通过其作为共同伴侣的作用。作为HSPA1B的协同伴侣,在细胞应激作用下,负调节BAX从胞浆向线粒体的转运,从而保护细胞不受凋亡的影响。促进细胞凋亡,以响应细胞应激介导的茴香霉素或紫外线。