靶标：
HSD11B1
产品别名：
11-DH； 11-beta-HSD1； CORTRD2； HDL； HSD11； HSD11B； HSD11L； SDR26C1； HSD11B1； hydroxysteroid 11-beta dehydrogenase 1； hydroxysteroid 11-beta dehydrogenase 1； 11-beta-hydroxysteroid dehydrogenase 1； 7-oxosteroid reductase； corticosteroid 11-beta-dehydrogenase isozyme 1； short chain dehydrogenase/reductase family 26C member 1； 11-β-羟基类固醇脱氢酶1(HSD11b1)； 羟基类固醇脱氢酶11β1；
背景信息：
hydroxysteroid 11-beta dehydrogenase 1(HSD11B1) Homo sapiens The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011],
