靶标:
HINT1
产品别名:
HINT; NMAN; PKCI-1; PRKCNH1; HINT1; histidine triad nucleotide binding protein 1; histidine triad nucleotide binding protein 1; adenosine 5'-monophosphoramidase HINT1; adenosine 5'-monophosphoramidase; desumoylating isopeptidase HINT1; epididymis secretory sperm binding protein; protein kinase C inhibitor 1; protein kinase C-interacting protein 1; 组氨酸三聚体核苷结合蛋白1;
背景信息:
This gene encodes a protein that hydrolyzes purine nucleotide phosphoramidates substrates, including AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif. This gene is considered a tumor suppressor gene. In addition, mutations in this gene can cause autosomal recessive neuromyotonia and axonal neuropathy. There are several related pseudogenes on chromosome 7. Several transcript variants have been observed. [provided by RefSeq, Dec 2015],