靶标:
HABP2
产品别名:
FSAP; HABP; HGFAL; NMTC5; PHBP; HABP2; hyaluronan binding protein 2; hyaluronan binding protein 2; hyaluronan-binding protein 2; factor VII activating protein; factor VII-activating protease; factor seven-activating protease; hepatocyte growth factor activator-like protein; hyaluronic acid binding protein 2; plasma hyaluronan binding protein; 透明质酸结合蛋白2; 透明质酸结合蛋白2 27kDa轻链; 透明质酸结合蛋白2 50kDa重链; 透明质酸结合蛋白2(HABP2);
背景信息:
This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by hepatocytes and proteolytically processed to generate heavy and light chains that form the mature heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This extracellular protease binds hyaluronic acid and may play a role in the coagulation and fibrinolysis systems. Mutations in this gene are associated with nonmedullary thyroid cancer and susceptibility to venous thromboembolism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016],