靶标：
GLE1
产品别名：
CAAHC； CAAHD； GLE1L； LCCS； LCCS1； hGLE1； GLE1； GLE1 RNA export mediator； GLE1 RNA export mediator； mRNA export factor GLE1； GLE1 RNA export mediator homolog； GLE1-like protein； GLE1-like, RNA export mediator； nucleoporin GLE1； 核孔蛋白GLE1；
背景信息：
This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
