靶标：
GHR
产品别名：
GHBP； GHIP； GHR； growth hormone receptor； growth hormone receptor； growth hormone receptor； GH receptor； growth hormone binding protein； mutant growth hormone receptor； serum binding protein； somatotropin receptor； 生长激素受体； 生长激素受体(GHR)；
背景信息：
This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011],
