靶标:
GGT5
产品别名:
GGL; GGT 5; GGT-REL; GGTLA1; GGT5; gamma-glutamyltransferase 5; gamma-glutamyltransferase 5; glutathione hydrolase 5 proenzyme; gamma-glutamyl cleaving enzyme; gamma-glutamyl transpeptidase-related enzyme; gamma-glutamyl transpeptidase-related protein; gamma-glutamyltransferase-like activity 1; gamma-glutamyltranspeptidase 5; leukotriene-C4 hydrolase; γ-谷氨酰基转氨酶5(gGT5); γ-谷氨酰转肽酶5轻链; γ-谷氨酰转肽酶5重链;
背景信息:
This gene is a member of the gamma-glutamyl transpeptidase gene family, and some reports indicate that it is capable of cleaving the gamma-glutamyl moiety of glutathione. The protein encoded by this gene is synthesized as a single, catalytically-inactive polypeptide, that is processed post-transcriptionally to form a heavy and light subunit, with the catalytic activity contained within the small subunit. The encoded enzyme is able to convert leukotriene C4 to leukotriene D4, but appears to have distinct substrate specificity compared to gamma-glutamyl transpeptidase. Alternative splicing results in multiple transcript variants encoding different isoforms.