靶标：
GFRA2
产品别名：
GDNFRB； NRTNR-ALPHA； NTNRA； RETL2； TRNR2； GFRA2； GDNF family receptor alpha 2； GDNF family receptor alpha 2； GDNF family receptor alpha-2； GDNF receptor beta； GDNFR-alpha-2； GDNFR-beta； GFR-alpha 2； NTNR-alpha； PI-linked cell-surface accessory protein； RET ligand 2； TGF-beta-related neurotrophic factor receptor 2； TRN receptor, GPI-anchored； glial cell line derived neurotrophic factor receptor, beta； neurturin receptor alpha； 胶质细胞系来源神经营养因子受体α2(GFRa2)； 胶质细胞系源性神经营养因子受体α2；
背景信息：
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009],
