靶标：
GDF1
产品别名：
CERS1； CHTD6； DORV； DTGA3； LAG1； LASS1； RAI； UOG1； GDF1； growth differentiation factor 1； growth differentiation factor 1； embryonic growth/differentiation factor 1； Ceramide synthase 1； LAG1 longevity assurance homolog 1； Longevity assurance gene 1 protein homolog 1； Protein UOG-1； 生长分化因子1； 生长分化因子1(GDF1)；
背景信息：
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. The encoded protein is translated from a bicistronic mRNA that also encodes ceramide synthase 1. Mutations in this gene are associated with several congenital cardiovascular malformations. [provided by RefSeq, Jul 2016],
