靶标:
FOXI1
产品别名:
FKH10; FKHL10; FREAC-6; FREAC6; HFH-3; HFH3; FOXI1; forkhead box I1; forkhead box I1; forkhead box protein I1; HNF-3/fork-head homolog-3; forkhead-like 10; forkhead-related activator 6; forkhead-related protein FKHL10; forkhead-related transcription factor 6; hepatocyte nuclear factor 3 forkhead homolog 3; 叉头蛋白I1;
背景信息:
Forkhead box I1 is a protein that in humans is encoded by the FOXI1 gene. It is mapped to 5q35.1. This gene belongs to the forkhead family of transcription factors,which is characterized by a distinct forkhead domain. This gene may play an important role in the development of the cochlea and vestibulum,as well as in embryogenesis. The encoded protein has been found to be required for the transcription of four subunits of a proton pump found in the inner ear,the kidney,and the epididymis. Mutations in this gene have been associated with deafness,autosomal recessive 4.