靶标：
ACSL4
产品别名：
ACS4； FACL4； LACS4； MRX63； MRX68； XLID63； ACSL4； acyl-CoA synthetase long chain family member 4； acyl-CoA synthetase long chain family member 4； long-chain-fatty-acid--CoA ligase 4； acyl-CoA synthetase 4； arachidonate--CoA ligase； fatty-acid-Coenzyme A ligase, long-chain 4； lignoceroyl-CoA synthase； long-chain acyl-CoA synthetase 4； long-chain fatty-acid-Coenzyme A ligase 4； 酰基辅酶A合成酶4；
背景信息：
Long-chain-fatty-acid—CoA ligase 4 is an enzyme that in humans is encoded by the ACSL4 gene. It is mapped to Xq23. The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the cognitive disability or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants.
