靶标：
F12
产品别名：
HAE3； HAEX； HAF； F12； coagulation factor XII； coagulation factor XII； coagulation factor XII； Hageman factor； beta-factor XIIa part 1； beta-factor XIIa part 2； coagulation factor XIIa heavy chain； coagulation factor XIIa light chain； 凝固第XII因子/抗血友病因子； 凝血因子12轻链； 凝血因子12重链； 凝血因子Ⅻ(F12)；
背景信息：
This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activat
