靶标:
ELAVL3
产品别名:
HUC; HUCL; PLE21; ELAVL3; ELAV like RNA binding protein 3; ELAV like RNA binding protein 3; ELAV-like protein 3; ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C); ELAV like neuron-specific RNA binding protein 3; Hu antigen C; hu-antigen C; paraneoplastic cerebellar degeneration-associated antigen; paraneoplastic limbic encephalitis antigen 21; 副肿瘤综合症小脑变性相关蛋白;
背景信息:
A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.