靶标：
ECH1
产品别名：
HPXEL； ECH1； enoyl-CoA hydratase 1； enoyl-CoA hydratase 1； delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial； delta3,5-delta2,4-dienoyl-CoA isomerase； delta3,5-delta2,4-dienoyl-coenzyme A isomerase； dienoyl-CoA isomerase； enoyl Coenzyme A hydratase 1, peroxisomal； enoyl-CoA hydratase 1, peroxisomal； epididymis secretory sperm binding protein； peroxisomal enoyl-CoA hydratase 1； 烯酰辅酶A水合酶1； 烯酰辅酶A水合酶1(ECH1)；
背景信息：
This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators.
