靶标:
DNASE2
产品别名:
AIPCS; DNASE2A; DNL; DNL2; DNASE2; deoxyribonuclease 2, lysosomal; deoxyribonuclease 2, lysosomal; deoxyribonuclease-2-alpha; DNase II alpha; DNase II, lysosomal; R31240_2; acid DNase; deoxyribonuclease II alpha; deoxyribonuclease II, lysosomal; lysosomal DNase II; 脱氧核糖核酸酶2; 脱氧核糖核酸酶Ⅱ(DNASEII);
背景信息:
This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record.