靶标：
DMBT1
产品别名：
GP340； SAG； SALSA； muclin； DMBT1； deleted in malignant brain tumors 1； deleted in malignant brain tumors 1； deleted in malignant brain tumors 1 protein； glycoprotein 340； hensin； salivary agglutinin； salivary scavenger and agglutinin； surfactant pulmonary-associated D-binding protein； vomeroglandin； 恶性脑肿瘤缺失蛋白1(DMBT1)； 抑癌基因；
背景信息：
Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. This gene was originally isolated based on its deletion in a medulloblastoma cell line. This gene is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The encoded protein precursor is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq, Mar 2016],
