靶标：
CYP2E1
产品别名：
CPE1； CYP2E； P450-J； P450C2E； CYP2E1； cytochrome P450 family 2 subfamily E member 1； cytochrome P450 family 2 subfamily E member 1； cytochrome P450 2E1； 4-nitrophenol 2-hydroxylase； CYPIIE1； cytochrome P450, family 2, subfamily E, polypeptide 1； cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1； cytochrome P450-J； flavoprotein-linked monooxygenase； microsomal monooxygenase； xenobiotic monooxygenase； 细胞色素P450ⅡE1； 细胞色素P450家族成员2E1(CYP2E1)；
背景信息：
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008],
