靶标：
CHRNA2
产品别名：
CHRNA2； cholinergic receptor nicotinic alpha 2 subunit； cholinergic receptor nicotinic alpha 2 subunit； neuronal acetylcholine receptor subunit alpha-2； acetylcholine receptor, nicotinic, alpha 2 (neuronal)； cholinergic receptor, nicotinic alpha 2； cholinergic receptor, nicotinic, alpha 2 (neuronal)； cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)； 烟碱型乙酰胆碱受体A2(神经型)； 烟碱型胆碱受体α2(CHRNa2)；
背景信息：
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. [provided by RefSeq, Nov 2009],
