靶标:
CHIT1
产品别名:
CHI3; CHIT; CHITD; CHIT1; chitinase 1; chitinase 1; chitotriosidase-1; chitinase 1 (chitotriosidase); plasma methylumbelliferyl tetra-N-acetylchitotetraoside hydrolase; 几丁质酶1; 几丁质酶1(CHIT1);
背景信息:
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012],