靶标：
CASP10
产品别名：
ALPS2； FLICE-2； FLICE2； MCH4； CASP10； caspase 10； caspase 10； caspase-10； CASP-10； FADD-like ICE2； FAS-associated death domain protein interleukin-1B-converting enzyme 2； ICE-like apoptotic protease 4； apoptotic protease MCH-4； caspase 10 apoptosis-related cysteine peptidase； caspase 10, apoptosis-related cysteine protease； interleukin-1B-converting enzyme 2； 半胱胺酸蛋白酶-10； 胱天蛋白酶10(CASP10)；
背景信息：
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011],
