靶标：
BMPR1A
产品别名：
10q23del； ACVRLK3； ALK-3； ALK3； BMPR-1A； CD292； SKR5； BMPR1A； bone morphogenetic protein receptor type 1A； bone morphogenetic protein receptor type 1A； bone morphogenetic protein receptor type-1A； BMP type-1A receptor； activin A receptor, type II-like kinase 3； activin receptor-like kinase 3； bone morphogenetic protein receptor, type IA； serine/threonine-protein kinase receptor R5； 骨成型蛋白受体1A； 骨成型蛋白受体1A(BMPR1A)；
背景信息：
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008],
