靶标:
AZU1
产品别名:
AZAMP; AZU; CAP37; HBP; HUMAZUR; NAZC; hHBP; AZU1; azurocidin 1; azurocidin 1; azurocidin; cationic antimicrobial protein 37; cationic antimicrobial protein CAP37; heparin-binding protein; neutrophil azurocidin; 天青杀素(AZU); 天青素/肝素结合蛋白;
背景信息:
Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. This gene encodes a preproprotein that is proteolytically processed to generate a mature azurophil granule antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, Nov 2015],