靶标：
ATP6V1E1
产品别名：
ARCL2C； ATP6E； ATP6E2； ATP6V1E； P31； Vma4； ATP6V1E1； ATPase H+ transporting V1 subunit E1； ATPase H+ transporting V1 subunit E1； V-type proton ATPase subunit E 1； ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1； H(+)-transporting two-sector ATPase, 31kDa subunit； H+-transporting ATP synthase chain E, vacuolar； V-ATPase 31 kDa subunit； V-ATPase subunit E 1； V-ATPase, subunit E； vacuolar proton pump subunit E 1；
背景信息：
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain E subunit isoforms. Pseudogenes for this gene have been found in the genome. [provided by RefSeq, Jul 2008],
