Amyloid-β (Aβ) (17-40) is a 24-residue fragment of the Aβ protein that is formed via post-translational processing of amyloid precursor protein (APP) by α- and γ-secretases.
货号:ajcx18090
CAS:N/A
分子式:C110H178N26O31S•XCF3COOH
分子量：2392.8
溶解度:Formic Acid: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Amyloid-β (Aβ) (17-40) is a 24-residue fragment of the Aβ protein that is formed via post-translational processing of amyloid precursor protein (APP) by α- and γ-secretases. In vitro, Aβ (17-40) polymerizes into lattice-like structures that do not bind thioflavin T. It inhibits interactions between fibrinogen and biotinylated Aβ (1-42) as well as between cholesterol and apolipoprotein E (ApoE) with IC50 values of 13.4 and 25 μM, respectively. Aβ (17-40) increases the rate of Aβ (1-40) aggregation in vitro when used at an equimolar concentration. Aβ (17-40) (25 μM) induces cell death in cultured rat hippocampal neurons.