AKOS-22 是一种有效的线粒体蛋白电压依赖性阴离子通道 1 (VDAC1) 抑制剂 (Kd=15.4 μM)。AKOS-22 与 VDAC1 相互作用，抑制 VDAC1 齐聚和凋亡。AKOS-22 对线粒体功能的保护作用。
货号:ajcx16976
CAS:878983-38-1
分子式:C22H21ClF3N3O3
分子量：467.87
溶解度:DMSO: 125 mg/mL (267.17 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

AKOS-22 is a potent mitochondrial protein VDAC1 (voltage-dependent anion channel 1) inhibitor (Kd=15.4 μM). AKOS-22 interacts with VDAC1 and inhibiting both VDAC1 oligomerization and apoptosis. AKOS-22 protects against mitochondrial dysfunction[1].

[1]. Ben-Hail D, et al. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protectagainst Mitochondrial Dysfunction. Biol Chem. 2016 Nov 25;291(48):24986-25003.