An inhibitor of MAO-A
货号:ajcx28392
CAS:116569-09-6
分子式:C8H5NO3
分子量：163.1
溶解度:DMF: 3 mg/ml,DMSO: 5 mg/ml,Ethanol: insol,PBS (pH 7.2): insol
纯度：98%
存储：Store at -20°C
库存：现货

Background:

5-hydroxy Isatin is an inhibitor of monoamine oxidase A (MAO-A; IC₅₀= 8.4 µM).¹It is selective for MAO-A over MAO-B (IC₅₀= >100 µM). 5-hydroxy Isatin (50 µM) also inhibits atrial natriuretic peptide-induced activation of particulate guanylyl cyclase in rat brain and heart membranes.²

1.Medvedev, A.E., Goodwin, B., Chow, A., et al.Inhibitory potency of some isatin analogues on human monoamine oxidase A and BBiochem. Pharmacol.44(3)590-592(1992) 2.Medvedev, A.E., Goodwin, B.L., Sandler, M., et al.Efficacy of isatin analogues as antagonists of rat brain and heart atrial natriuretic peptide receptors coupled to particulate guanylyl cyclaseBiochem. Pharmacol.57(8)913-915(1999)