Apimostinel是门冬氨酸受体(NMDAreceptor)的部分激动剂。
货号:ajcx12462
CAS:1421866-48-9
分子式:C25H37N5O6
分子量：503.59
溶解度:DMSO: 155 mg/mL (307.79 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Apimostinel is an oral NMDA receptor partial agonist.

Apimostinel (NRX-1074) modulates the NMDA receptor in a similar fashion to GLYX-13, but has a synthetic modification to one of the amino acids, conferring increased potency and oral bioavailability[1].

In preclinical models the two compounds both appear to be highly efficacious across a number of CNS disorders[1].

[1]. Naurex's First Orally Active Molecule, NRX-1074, Demonstrates Statistically Significant Improvement in Depression Scores within 24 Hours in Phase 2 Study for Major Depressive Disorder. January 28, 2015.