APC 366 is a mast cell tryptase inhibitor (Ki = 7.1 μM for human recombinant enzyme).
货号:ajcx18106
CAS:N/A
分子式:C22H28N6O4•XCF3COOH
分子量：440.5
溶解度:Ethanol:Water: 5 mg/ml (in 20% EtOH)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

APC 366 is a mast cell tryptase inhibitor (Ki = 7.1 μM for human recombinant enzyme). It reduces maximum contractile response to histamine in isolated bronchial tissue from ovalbumin-sensitized guinea pigs when used at a concentration of 1 μM. Aerosolized APC 366 (5 mg in 1 ml of water) reduces airway resistance and increases dynamic lung compliance in A. suum antigen-challenged pigs. It also reduces collagen content and expression of protease-activated receptor 2 (PAR-2) and α-smooth muscle actin (α-SMA) in rat liver in a model of bile duct ligation-induced liver fibrosis.