An active metabolite of cytarabine
货号:ajcx26644
CAS:7075-11-8
分子式:C9H14N3O8P
分子量：323.2
溶解度:Water: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Cytarabine 5′-monophosphate (ara-CMP) is an active metabolite of the nucleoside analog cytarabine .¹It is formed from cytarabine by deoxycytidine kinase.²ara-CMP is incorporated into DNA by DNA polymerase α, which slows the rate of DNA synthesis by approximately 2,000-fold in a cell-free assay.³It inhibits nuclear and mitochondrial DNA replication inS. cerevisiaewhen used at a concentration of 15 mM.⁴ara-CMP (3.5-75.1 mg/kg) improves survival in an L1210 murine leukemia model.⁵

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