SM-433 是一种 Smac 模拟物，是一种凋亡抑制蛋白 (IAPs) 的抑制剂发挥作用。SM-433 表现出强结合亲和力 XIAP BIR3 蛋白，IC50<1μM。(详细信息来自专利 WO2008128171A2)。
货号:ajcx35204
CAS:1071992-81-8
分子式:C32H43N5O4
分子量：561.71
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SM-433, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 exhibits strong binding affinity XIAP BIR3 protein with an IC50<1 μM. (patent WO2008128171A2)[1].

SM-433 exhibits strong inhibitory activity against MDA-MB -2131 human breast cancer cells and SK-OV-3 ovarian cancer cells (IC50s<10 μM, respectively)[1].

[1]. Shaomeng Wang, et al. Diazo bicyclic smac mimetics and the uses thereof. WO2008128171A2.