4-oxo Withaferin A

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4-oxo Withaferin A

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规格:	98%
分子量:	468.6

包装与价格：

包装	价格(元)
1mg	询价
10mg	询价
5mg	询价

C28H36O6
货号:ajcx19258
CAS:6850-30-2
分子式:C28H36O6
分子量：468.6
溶解度:DMF: 5mg/mL,DMSO: 5mg/mL,DMSO:PBS (pH 7.2) (1:1): 0.5mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

4-oxo Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells and carboplatin-resistant A2780 (A2780/CP70) cells (IC50s = 7.3 and<1 μM, respectively) and is 4.4-fold selective for A2780 cells over non-cancerous ARPE19 cells.

参考文献
1. Perestelo, N.R., Llanos, G.G., Reyes, C.P., et al. Expanding the chemical space of withaferin A by incorporating silicon to improve its clinical potential on human ovarian carcinoma cells. J. Med. Chem. 62(9), 4571-4585 (2019).