EZH2/EDD interaction inhibitor; suppresses PCR2 complex function
货号:ajcx27782
CAS:1453222-26-8
分子式:C155H256N48O40
分子量：3432.05
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

EZH2/EPP interaction inhibitor (Kd = 320 nM). Suppresses EZH2 expression and H3K27 trimethylation by PCR2 complex. Arrests proliferation and induces monocyte to macrophage differentiation of MLL-AF9 leukemia cell line.

Kim et al (2013) Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nat.Chem.Biol. 9 643 PMID:23974116 |Kim et al (2015) SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2. Nat.Med. 21 1491 PMID:26552009