ISPA-28 是特异性的疟原虫表面阴离子通道 (PSAC) 拮抗剂。ISPA-28 直接可逆的与CLAG3 结合。
货号:ajcx33548
CAS:1006335-39-2
分子式:C21H24N6O3
分子量：408.45
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ISPA-28 is a specific plasmodial surface anion channel (PSAC) antagonist. ISPA-28 binds directly and reversibly to CLAG3[1][2].

ISPA-28 is only effective as an inhibitor of Dd2 channels (K0.5 values of 56 nM and 43 μM for Dd2 and HB3 channels, respectively)[2].

[1]. Sanjay A Desai, et al. Ion and Nutrient Uptake by Malaria Parasite-Infected Erythrocytes.
[2]. Wang Nguitragool, et al. Proteolysis at a Specific Extracellular Residue Implicates Integral Membrane CLAG3 in Malaria Parasite Nutrient Channels.