MC-Val-Cit-PAB Linker 1

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

规格:	98%
分子量:	591.1

MC-Val-Cit-PAB-Cl 是基于季铵的生物可逆连接，用于靶向递送，可以改善药代动力学和治疗指数。MC-Val-Cit-PAB-Cl 用于体外和体内有效且稳定的抗体-药物偶联物 (antibody-drug conjugates) 以治疗各种疾病或病症。
货号:ajcx13998
CAS:N/A
分子式:C28H39ClN6O6
分子量：591.1
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

MC-Val-Cit-PAB-Cl has a bioreversible linkage based on a quaternary ammonium for targeted delivery and it can improve pharmacokinetics and the therapeutic index. MC-Val-Cit-PAB-Cl is used for the antibody-drug conjugates (ADC) that are effective and stable in vitro and in vivo to treat various diseases or disorders [1].

[1]. Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119.