D-3 是一种磷肽，是一种高效、简单且特异性的 iPSC 消除剂。
货号:ajcx27700
CAS:1967815-98-0
分子式:C48H47N4O10P
分子量：870.88
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Selective PSC eliminating agent. Induces toxicity in cultured iPSCs and ESCs after 1 h of incubation, via an alkaline phosphatase-dependent mechanism. Only eliminates iPSCs in co-cultures with iPSC-derived neurons, cardiomyocytes or hepatocytes. Treated iPSC-derived cardiomyocytes transplanted into mice exhibit no residual teratoma formation.

Kuang et al (2017) Efficient, selective removal of human pluripotent stem cells via ecto-alkaline phosphatase-mediated aggregation of synthetic peptides. Cell Chem.Biol. 24 685 PMID:28529132