Pelcitoclax (APG-1252) 是一种有效的 Bcl-2/Bcl-xl 抑制剂，具有抗肿瘤和促凋亡作用。
货号:ajcx33854
CAS:1619923-36-2
分子式:C57H66ClF4N6O11PS4
分子量：1281.85
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Pelcitoclax (APG-1252) is a potent Bcl-2/Bcl-xl inhibitor with antineoplastic and pro-apoptotic effects[1].

APG-1252 changes to the reactive metabolite named APG-1252-M1, which has remarkable antitumor effects in acute myeloid leukemia[1].

Pelcitoclax (APG-1252; 25-100 mg/kg; i.v.; once a day; for 10days) treatment inhibits xenograft tumor growth more obviously than the other groups[1].

[1]. Hanjie Yi, et al. Bcl-2/Bcl-xl inhibitor APG-1252-M1 is a promising therapeutic strategy for gastric carcinoma. Cancer Med. 2020 Jun;9(12):4197-4206.